San Francisco 49ers @ New York Giants
Kickoff (ET): 2025-11-02 13:00

Primary Picks

Top picks, period.
San Francisco 49ers Moneyline
San Francisco 49ers
FanDuel (-142)

Market has San Francisco a short road favorite and their offense is more bankable with Christian McCaffrey and George Kittle while New York’s passing game leans on rookie Jaxson Dart behind a line that has already allowed 17 sacks. The Giants are without Malik Nabers (I.L.) and have several questionable pieces (e.g., Jermaine Eluemunor), limiting explosive potential, while SF’s short-area passing with Mac Jones has been efficient (266.2 pass yds/g). Even with some 49ers defensive injuries, SF’s offensive consistency and red-zone edge tilt the result. Hit Confidence: 7.6/10

Confidence: 7.6/10
Under 48.5
BetMGM (-110)

Both teams project to lean on underneath/ball-control concepts (CMC/Kittle usage; Dart QB runs) which should bleed clock, and the WR rooms are thinned (Aiyuk PUP-eligible; Nabers I.L.) reducing explosive play odds. Kicking markets (Eddy Pineiro prolific, perfect 17/17) imply stalled drives into field goals rather than touchdowns. With a modest spread and SF likely to dictate pace on the ground, the ceiling is capped. Hit Confidence: 7.8/10

Confidence: 7.8/10
San Francisco 49ers — Spread -2.5
San Francisco 49ers
FanDuel (-110)

This aligns with the ML view: SF’s short passing and run game should sustain drives while the Giants’ offense is more volatile and banged up at receiver. SF’s protection issues are mitigated by a quick game that exploits NYG underneath, supporting a one-score road cover. Hit Confidence: 7.4/10

Confidence: 7.4/10

Player Props

Predicted player action.
Over 5.5 receptions
Christian McCaffrey — San Francisco 49ers
DraftKings (-122)

CMC owns 56 catches on 74 targets (7.0 rec/g) and Mac Jones’ profile plus NYG pressure tendency funnel throws to the back; with Brandon Aiyuk not at full availability, the target floor remains high. Giants’ injuries at the second level further open option routes and checkdowns. Hit Confidence: 8.3/10

Confidence: 8.3/10
Over 4.5 receptions
George Kittle — San Francisco 49ers
DraftKings (-103)

With WR injuries compressing SF’s target tree, Kittle’s route share and middle-field usage rise against a Giants unit missing key LB/slot support (e.g., Micah McFadden I.L.). Jones has shown willingness to work the seam/outlet game, and Kittle already has 2 TDs on limited volume that should climb here. Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 3.5 receptions
Kendrick Bourne — San Francisco 49ers
DraftKings (-106)

Bourne has 28 receptions on 39 targets (71.8% catch rate) and projects for steady intermediate work with SF’s WR room thin; NYG’s banged-up CB group invites chain-moving concepts. Expect packaged RPO/quick hitters to Bourne to complement CMC/Kittle. Hit Confidence: 7.7/10

Confidence: 7.7/10
Over 48.5 receiving yards
Jauan Jennings — San Francisco 49ers
FanDuel (-114)

Jennings’ aDOT and 11.8 YPR fit SF’s play-action and glance routes, and with Aiyuk limited the intermediate-X role expands; he owns three 20+ yard gains already. NYG’s secondary injuries open windows on in-breakers and crossers that can generate YAC. Hit Confidence: 7.4/10

Confidence: 7.4/10
Over 242.5 passing yards
Mac Jones — San Francisco 49ers
DraftKings (-112)

Jones’ baseline (266.2 yds/g) clears this mark and SF’s scheme leverages YAC via CMC/Kittle/Bourne to inflate totals even on modest aDOT. With NYG likely to force multiple passing sequences and SF’s run game drawing attention, intermediate windows should stay open. Hit Confidence: 7.2/10

Confidence: 7.2/10
Over 30.5 pass attempts
Jaxson Dart — New York Giants
FanDuel (-114)

As a small home dog, game script skews Dart toward volume, especially if NYG struggles to run vs. SF fronts; his mobility adds dropbacks through scrambles/sacks that still count as pass plays called. Injuries at WR narrow reads to TE/slot, but trailing pressure amplifies attempts. Hit Confidence: 7.0/10

Confidence: 7.0/10

Favored Four

Parlay package, for the favorite.
San Francisco 49ers Moneyline
San Francisco 49ers
FanDuel (-142)

SF’s short passing to CMC/Kittle plus a better overall offensive floor than NYG should carry a tight road win. Hit Confidence: 7.6/10

Confidence: 7.6/10
Over 5.5 receptions
Christian McCaffrey — San Francisco 49ers
DraftKings (-122)

CMC averages 7.0 receptions with heavy checkdown usage and faces a Giants defense that invites RB targets when pressured. Hit Confidence: 8.3/10

Confidence: 8.3/10
Over 4.5 receptions
George Kittle — San Francisco 49ers
DraftKings (-103)

With WR health uncertain, Kittle’s middle-of-field role expands against NYG’s undermanned underneath coverage. Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 3.5 receptions
Kendrick Bourne — San Francisco 49ers
DraftKings (-106)

Bourne’s steady target share and SF’s quick-game script support 4+ catches to move the chains. Hit Confidence: 7.7/10

Confidence: 7.7/10

Upset Alert

Parlay package, for the faithful.
New York Giants +2.5
New York Giants
BetMGM (-102)

Home dog catching under a field goal with a mobile QB profile creates backdoor and variance paths if the defense can force SF to settle for 3s. Hit Confidence: 7.2/10

Confidence: 7.2/10
Over 30.5 pass attempts
Jaxson Dart — New York Giants
FanDuel (-114)

If NYG covers, it likely correlates with Dart volume in a pass-leaning script and late drives extending attempts. Hit Confidence: 7.0/10

Confidence: 7.0/10
Over 34.5 rushing yards
Jaxson Dart — New York Giants
FanDuel (-114)

Designed keepers and scrambles vs. SF pressure are NYG’s chain-mover, and Dart already has 195 rush yards and 4 TDs. Hit Confidence: 7.1/10

Confidence: 7.1/10
Over 3.5 receptions
Darius Slayton — New York Giants
DraftKings (135)

With Nabers out, Slayton’s target share elevates and short/intermediate volume is the path if NYG hangs inside the number. Hit Confidence: 6.9/10

Confidence: 6.9/10

Defense & Dessert

Offense isn't everything.
Over 1.5 field goals
Eddy Pineiro — San Francisco 49ers
DraftKings (-135)

SF’s efficient but conservative red-zone tendencies with a short spread set up multiple drives stalling in 30–40 yard range for Pineiro (17/17 FGs). Hit Confidence: 8.0/10

Confidence: 8.0/10
Under 1.5 field goals
Graham Gano — New York Giants
DraftKings (-112)

As a home dog, NYG are more likely to chase touchdowns or go for fourth downs rather than settle for multiple long FG tries versus SF. Hit Confidence: 7.7/10

Confidence: 7.7/10
Over 0.5 interceptions thrown
Mac Jones — San Francisco 49ers
DraftKings (-125)

Jones has 5 INTs and 14 sacks taken, and compressed downfield options increase risk of a forced throw versus disguised NYG coverages. Hit Confidence: 7.8/10

Confidence: 7.8/10
Over 0.5 interceptions thrown
Jaxson Dart — New York Giants
FanDuel (-128)

A rookie passer likely throwing from behind invites one turnover against SF’s post-snap rotations even without some star defenders. Hit Confidence: 7.6/10

Confidence: 7.6/10