Kansas City Chiefs @ Buffalo Bills
Kickoff (ET): 2025-11-02 16:25

Primary Picks

Top picks, period.
Kansas City Chiefs Moneyline
Kansas City Chiefs
DraftKings (-130)

Market has Kansas City a short road favorite, and the matchup tilts toward Mahomes against a Bills defense missing key interior pieces (Ed Oliver I.L., DaQuan Jones Q) and DB depth (Taylor Rapp I.L.). If Isiah Pacheco (Q) is limited, Kansas City’s pass rate and RPO usage should spike, leveraging Rashee Rice/Travis Kelce in space versus zone. Buffalo will move it with James Cook, but Kansas City’s pass efficiency and multiple playmakers give them the higher late‑game floor. Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 52.5
FanDuel (-108)

A 52.5 total with a tight spread signals a shootout script: Buffalo’s explosive ground game (James Cook 6.0 YPC, 107.6 rush YPG) plus K.C.’s high‑volume passing should sustain drives and explosives. Defensive attrition on Buffalo’s front and Kansas City’s emphasis on Rice/Kelce underneath elevate scoring efficiency on both sides. Hit Confidence: 8.1/10

Confidence: 8.1/10
Kansas City Chiefs — Spread -1.5
Kansas City Chiefs
FanDuel (-114)

Correlated with the ML: Mahomes’ edge in late‑down passing and Andy Reid’s pass-centric tilt if Pacheco is limited support K.C. winning by a FG in a high‑total environment. Bills can trade blows via Cook and play‑action, but K.C.’s receiving depth and QB advantage close the gap. Hit Confidence: 7.7/10

Confidence: 7.7/10

Player Props

Predicted player action.
Over 35.5 pass attempts
Patrick Mahomes — Kansas City Chiefs
DraftKings (-124)

Tight spread plus elevated total points to pass volume, and Pacheco’s knee (Q) further nudges K.C. toward Mahomes-led scripts; he’s averaging ~35 attempts per game with scramble/drift checkdowns when pressured. Bills’ injuries on the back end invite high-percentage throws to Kelce/Rice/Worthy, sustaining attempts into the 4th. Hit Confidence: 8.3/10

Confidence: 8.3/10
Over 72.5 receiving yards
Rashee Rice — Kansas City Chiefs
DraftKings (-114)

Primary target with YAC juice (87 YAC on 16 catches) in a scheme that manufactures space; Buffalo’s zone looks and injuries make him the chain-mover and explosive creator. Correlates with Mahomes volume and a game total north of 52—Rice should clear on eight-plus targets. Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 4.5 receptions
Travis Kelce — Kansas City Chiefs
DraftKings (114)

Kelce’s role remains bankable (37 receptions on 48 targets), and Buffalo’s safety/nickel attrition funnels work to seams and option routes. High total plus late-game two‑minute potential elevate catch floor beyond five. Hit Confidence: 8.1/10

Confidence: 8.1/10
Over 51.5 receiving yards
Khalil Shakir — Buffalo Bills
DraftKings (-110)

Shakir (50.9 YPG) has evolved into Buffalo’s primary WR option with strong slot usage and intermediate separation; K.C. concedes underneath in exchange for capping explosives. Pace and catch-up windows in a projected shootout should push 7–9 targets. Hit Confidence: 7.8/10

Confidence: 7.8/10
Over 74.5 rushing yards
James Cook — Buffalo Bills
DraftKings (-115)

Cook’s efficiency is elite (6.0 YPC) with sustained volume (107.6 rush YPG) and explosive capability; K.C.’s two‑high structures invite Buffalo’s ground game to stay balanced. Even in trailing scripts, Cook’s chunk gains and red‑zone leverage keep him live for 80+. Hit Confidence: 8.0/10

Confidence: 8.0/10
Over 28.5 rushing yards
Patrick Mahomes — Kansas City Chiefs
DraftKings (-111)

Mahomes is averaging 35.0 rush YPG with designed keepers and scramble lanes when defenses play man/quarters vs. K.C. option routes; Bills’ coverage shells and stunts open middle escape paths. High leverage 3rd/4th downs further boost scramble equity. Hit Confidence: 8.2/10

Confidence: 8.2/10

Favored Four

Parlay package, for the favorite.
Kansas City Chiefs Moneyline
Kansas City Chiefs
DraftKings (-130)

Mahomes’ passing edge against a banged‑up Bills front/seconday in a high‑total, tight-spread game tilts the late downs to K.C. finishing drives. Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 4.5 receptions
Travis Kelce — Kansas City Chiefs
DraftKings (114)

Buffalo’s nickel/safety injuries funnel targets to Kelce’s option routes and hot reads, making 5–7 catches the median in this script. Hit Confidence: 8.1/10

Confidence: 8.1/10
Over 35.5 pass attempts
Patrick Mahomes — Kansas City Chiefs
DraftKings (-124)

With Pacheco (knee) questionable and a 52.5 total, K.C. is incentivized to lean into pass volume and RPOs all game. Hit Confidence: 8.3/10

Confidence: 8.3/10
Over 72.5 receiving yards
Rashee Rice — Kansas City Chiefs
DraftKings (-114)

Primary YAC WR in a condensed tree versus zone looks has a path to eight-plus targets and multiple explosives. Hit Confidence: 7.9/10

Confidence: 7.9/10

Upset Alert

Parlay package, for the faithful.
Buffalo Bills — Spread +2
Buffalo Bills
BetMGM (-110)

Buffalo can control tempo with James Cook’s explosive run game while Allen distributes underneath to Shakir/Kincaid to keep this within a field goal. Hit Confidence: 7.6/10

Confidence: 7.6/10
Over 17.5 rush attempts
James Cook — Buffalo Bills
FanDuel (110)

If Buffalo leads or keeps neutral script, Cook’s 20‑touch profile and 6.0 YPC efficiency underpin a run‑leaning plan to shorten possessions. Hit Confidence: 7.8/10

Confidence: 7.8/10
Over 50.5 receiving yards
Khalil Shakir — Buffalo Bills
FanDuel (-114)

Shakir’s WR1 usage and slot separation versus K.C.’s zone give Buffalo steady chain movement in an upset script. Hit Confidence: 7.7/10

Confidence: 7.7/10
Under 45.5 rushing yards
Kareem Hunt — Kansas City Chiefs
FanDuel (-114)

In a Bills-forward script, K.C. skews to Mahomes’ arm, capping Hunt’s carries and making sub‑46 rushing yards a strong correlation play. Hit Confidence: 7.5/10

Confidence: 7.5/10

Defense & Dessert

Offense isn't everything.
Over 1.5 field goals
Harrison Butker — Kansas City Chiefs
DraftKings (108)

High-possession game with some RZ resistance should yield 2+ attempts for a trusted leg in Butker (12/15 with three 50+ makes). Hit Confidence: 7.9/10

Confidence: 7.9/10
Over 0.5 sacks
Chris Jones — Kansas City Chiefs
FanDuel (154)

Jones’ interior win rate versus a Bills line that will be in frequent true pass sets in a shootout gives strong pressure-to-sack conversion. Hit Confidence: 7.6/10

Confidence: 7.6/10
Over 0.5 sacks
George Karlaftis — Kansas City Chiefs
FanDuel (130)

Edge pressure opposite Jones plus late‑down volume from Buffalo creates opportunistic cleanup sack chances. Hit Confidence: 7.5/10

Confidence: 7.5/10
Over 0.5 sacks
Joey Bosa — Buffalo Bills
FanDuel (120)

Bosa’s burst and counter game versus extended Mahomes dropbacks offers multiple high‑win rush reps to cash 1 sack. Hit Confidence: 7.4/10

Confidence: 7.4/10